| Analysis methods | Availability | Number of genes | Test code | Retail Price |
|---|---|---|---|---|
| PCR | 3 – 4 weeks | GHC 037 | £ TBA |
Detailed information
The BRCA1,2 screen genetic analysis detects the presence of the 24 most frequent
mutations of the BRCA genes in our population that lead to an increased risk of cancer,
including inherited risk. This test enables the detection of 60.5% of the most frequent
mutations in the BRCA1 gene and 36.2% of mutations in the BRCA2 gene. It is the only
product on the market that can assess the lifetime risk of breast, ovarian and fallopian
tube cancer to such a large extent. The genetic analysis is based on the latest expertise
and extensive GHC Genetics database.
With the BRCA1,2 screen test, you can find out your congential risk of breast,
ovarian or fallopian tube cancer. If you have an increased risk of cancer, we
will give you specific recommendations for preventive treatment. Part of the
prevention of oncological disease is the adoption of a healthy lifestyle, which
includes exercise, proper nutrition, adherence to a drinking regime, avoiding
stress, obesity, smoking or excessive consumption of alcohol.
Breast cancer is one of the most common malignant tumours in women and its incidence
in this country has continued to increase in recent years. Ovarian and fallopian tube
cancer represent another 15% of all malignant tumours in women. Although the risk
of developing these diseases increases with age and the most frequent occurrence
is between the age of 50 and 60, in case of congential predisposition, however, the
disease can manifest after the age of 30.
About 5-10% of all breast cancers concern so-called hereditary breast and ovarian
cancer syndrome, which is due to a congenital BRCA gene mutation. The BRCA1 and
BRCA2 genes prevent uncontrolled cell division and aid in DNA repair. Mutations in
these genes significantly increase the risk of cancer. There is a 2-4 times higher risk of
other malignant tumours (e.g. colorectal, abdomen, pancreas, prostate, gall bladder,
bile duct or malignant melanoma) in all carriers of this mutation, including men,
compared to the normal population.
Who is the test suitable for?
- Has someone in your family had breast, ovarian or fallopian tube cancer?
Have you had hormone replacement therapy following menopause?
Did you go into menopause after the age of 55?
Did you give birth to your first child after the age of 30?
Have you been / are you overweight in connection with menopause?
If you answered yes to any of these questions, we recommend you undergo our screen genetic test.
How does the test work?
Genetic examination is performed from your DNA, which can be obtained by swabbing from the oral cavity (buccal wiping of the inside of your mouth cheek - DNA isolation from oral mucosal cells). You can take the sample yourself in the comfort of your home and send it to our lab, or have your collection taken by your GP.
How is the test done?
You can order the test from attending your Doctor/GP, private clinic or online at ghcgenetics. co.uk. Once you have signed the informed consent form, either a swab of your mouth will be taken or a blood sample will be collected. Once the genetic analysis is finished, you or your Doctor/GP will receive a report with the results and based on these he/she will recommend suitable preventive measures.
