Resistance to HIV

Mutation of the chemokine receptor CCR5.

In HIV research, scientists have come up with very interesting findings.

Analysis methods Availability Number of genes Test code Retail Price
PCR 3 – 4 weeks GHC 042 £ TBA

Detailed information

Some people who have very often come into contact with HIV-positive blood have either not been HIV-positive or HIV-positive. This has led Scientists to develop a genetic examination of the differences between HIV-positive people and those who, though they could, did not become HIV-positive.

Scientists have even found several genes, some of which protect humans from HIV infection or, in the event of an infection, this virus will make life unusual for humans. The virus requires access to the cell to have receptors that allow it to enter the cell. These receptors include, for example, CD4, but also the presence of the CCR5 or CXCR4 co-receptor. As has been shown in recent years, the CCR5 mutation leads to HIV resistance or better prognosis after infection.

HIV-1 virus entry into the cell is mediated by a surface glycoprotein that gradually interacts with two receptors on the cell surface. It first binds to CD4 and then to one of the two chemokine receptors - CCR5 or CXCR4. CCR5 Chemokine (CC motif) receptor 5 is a chemokine receptor appearing on the surface of T lymphocytes, macrophages, dendritic cells and microglia cells.

CCR5 has its role in inflammatory reactions and infections. The CCR5 receptor is essential for the transmission of a person-to-person virus by sexual contact or blood. Molecules bound to this receptor include, e.g., RANTES, MIP-1α and MIP-1β. Some studies have shown that binding of these molecules to CCR5 receptors can suppress HIV infection (in vitro) and several drugs have been developed based on CCR5 receptor binding inhibitors with HIV.

The examination is appropriate if:

  • You want to know your risk of HIV infection
  • You are often exposed to the risk of HIV infection

Who is the test suitable for?

Genetic analysis of HIV resistance in no way tests the presence of the virus in the body. This genetic test is not an HIV test; on the contrary, it gives clients the opportunity to test for HIV resistance, ie the resistance of the individual to infection by this virus.

Who can this test reveal?

The outcome of the test, which means a reduced risk of HIV infection, may partially reassure people who, for example, are often at risk of HIV infection in the profession. The test will also help HIV-positive people to diagnose the prognosis of the disease and recommend the most appropriate treatment approach. Reduced risk of HIV infection does not mean that the test person cannot become infected with HIV. Such a person is only more likely to remain HIV negative when contacted with the virus.

How does the test work?

Genetic examination is performed from your DNA, which can be obtained by swabbing from the oral cavity (buccal wiping of the inside of your mouth cheek - DNA isolation from oral mucosal cells). You can take the sample yourself in the comfort of your home and send it to our lab, or have your collection taken by your GP.

How is the test done?

You can order the test from attending your Doctor/GP, private clinic or online at ghcgenetics. Once you have signed the informed consent form, either a swab of your mouth will be taken or a blood sample will be collected. Once the genetic analysis is finished, you or your Doctor/GP will receive a report with the results and based on these he/she will recommend suitable preventive measures.