TROMBOGEN® Safe Contraception

Safe Contraception with GHC TromboGen.

Thanks to this test, you can find out whether you have any genetic predisposition to thrombosis (blood clotting).

Analysis methods Availability Number of genes Test code Retail Price
PCR 3 – 4 weeks GHC 038 £ TBA

Detailed information

When using hormonal contraceptives, blood becomes more hypercoagulable or viscous.

The risk of developing thrombi (blood clots) is 2-4 times higher in women using hormonal contraception compared to women who do not use it. If you have an inherited predisposition to hypercoagulability, in other words if you are a carrier of a thrombophilic mutation, you may run as much as an 80-fold risk when taking hormonal contraceptives of developing thrombosis and its associated serious complicationspulmonary embolism, myocardial infarction or stroke.

Basic risk factors

  • Have you ever suffered from deep vein thrombosis and/or pulmonary embolism?
  • Have you had a myocardial infarction or stroke?
  • Have you had two or more miscarriages?
  • Have you had a miscarriage in the 2nd or 3rd trimester?
  • Was your pregnancy complicated by any of the following: intrauterine fetal growth restriction; premature separation (abruption) of the placenta and/or placental infarction (thrombosis); preeclampsia (high blood pressure and kidney failure)?
  • Are you unable to conceive with your partner? Are you planning IVF?
  • Have any of your blood relatives had deep vein thrombosis and/or pulmonary embolism, myocardial infarction or stroke?

Can this be prevented?

Thanks to the TromboGen® test, you can find out whether you have any genetic predisposition to thrombosis (blood clotting). If you are found to be a carrier of a thrombophilic mutation, a suitable type of contraception will be recommended and a preventive follow-up will be arranged in order to avoid the aforementioned complications. At the same time, it is also advisable to adjust one´s lifestyle- sufficient exercise; a suitable and rational diet and adherence to the general recommendations for the prevention of thrombosis (cessation of smoking, sufficient fluid intake, losing weight in the case of obesity and wearing compressive tights in the case of varicose veins).

How does the test work?

Genetic examination is performed from your DNA, which can be obtained by swabbing from the oral cavity (buccal wiping of the inside of your mouth cheek - DNA isolation from oral mucosal cells). You can take the sample yourself in the comfort of your home and send it to our lab, or have your collection taken by your GP.

How is the test done?

Your gynaecologist will go over your personal and family medical history with you and based on this information he/she will determine whether the TromboGen® test will be reimbursed by your health insurance company or not. Once you have signed the informed consent form, either a swab of your mouth will be taken or a blood sample will be collected. Once the genetic analysis is finished, your physician will receive a report with the results and based on these he / she will recommend suitable preventive measures. If a mutation is uncovered, you will be referred for genetic consultation (there, it will be recommended that the rest of your family members undergo testing) and for a haematological exam.